RESPUESTA DEL SISTEMA ENDOCRINO FRENTE A UN ESTÍMULO NÓXICO
De Dolopedia
- Enlaces de interés : Respuesta frente a un estímulo nóxico
- The hypothalamo-pituitary-adrenal (HPA) axis is the principal neuroendocrine component of the response to stress. Exposure to acute stress results in release of corticotrophin-releasing factor (CRF) from neurones of the hypothalamic paraventricular nucleus (PVN) which terminate in the median eminence. CRF then stimulates release of adrenocorticotrophic hormone (ACTH) from the anterior pituitary, which travels in the systemic circulation to induce the synthesis and release of glucocorticoids from the adrenal cortex: cortisol in humans or corticosterone in rodents .
- The endocrine system uses systemic circulation to evoke system-wide messaging and feedback.
- From the pain perspective, the stress response has several key properties:
- First, noxious signaling is among its triggers.
- Second, the overall reaction to the stressor includes both anticipatory and reactive responses.
- Third, these responses occur in multiple, hierarchically organized, or nested, neurocircuitries.
Furthermore, the stress response is not limited to the HPA axis but invariably involves multiple limbic brain